One of the talents you will need to recruit for this quest is 'The Lonesome Drifter.' He is located in front of the Sunset Sarsaparilla sign near the El Dorado Gas & Service. You can obtain this weapon during the 'Talent Pool' quest obtained from Tommy Torini at the Tops Casino (you will want to have at least 50 barter before this quest in order to obtain this special weapon). In any case it's pretty darn powerful (and seems to have a low degradation). I disagree with that, however, as I'd put 'Euclid's C-Finder' at # 1 (given that you directed power to Archimedes II during the 'That Lucky Old Sun' quest), then the 'Alien Blaster' at # 2, 'Pew Pew' at # 3, and then the weapon of topic for this thread, the 'Mysterious Magnum,' at # 4.
I have discovered a way to obtain said weapon, which according to Fallout Wiki is the second most powerful weapon in the game. If you are familiar with the 'Mysterious Stranger' perk, then you may be familiar with the unique. I just found something pretty cool that some of you may have already discovered, but wanted to share for those that haven't.